| Dusnic | Valencia |
| Dygicom | Tarragona |
| Dyna Tech | Barcelona |
| Dynamo.Video | Barcelona |
| E-creasolutions | Madrid |
| e-LAND Soluciones Digitales | |
| e-NetBlue | Madrid |
| E-nvía | Barcelona |
| e-SORT | Madrid |
| E3 Consultores Informáticos | Valencia |
| EAcom Systems, S.L. | Madrid |
| EADA Business School | Barcelona |
| EADE - Estudios Universitarios | |
| EADe comunicació | Lleida |
| EAE Business School | |
| EALDE Business School | |
| Earcon, S.L. | Barcelona |
| Easo Ventures | Gipuzkoa |
| Easy Code | A Coruña |
| EasyVoIP | Santa Cruz de Tenerife |
| Eccocar Sharing, S.L. | Madrid |
| Eccuo | |
| ECIJA | Madrid |
| Ecinsa | Madrid |
| Eclickse Digital, S.L. | Biscay |
| Eclom Services | Madrid |
| Ecna Informática, S.L. | Biscay |
| Ecocomputer, S.L. | Asturias |
| Ecom Telecomunicaciones | Valencia |
| Ecomspain Conectividad, S.L. | Madrid |
| EcoMT | A Coruña |
| Econocom, S.A. | Madrid |
| Ecoplanet Way, S.L. | Madrid |
| Ecoscooting Delivery, S.L. | Madrid |
| eData Desarrollo Web | Barcelona |
| Edataconsulting, S.L. | Las Palmas |
| Edesign-Comunicacion.com | Barcelona |
| EdgeWatch | Valencia |
| Edisa Sistemas de Información, S.A. | Ourense |
| eDise Soluciones | Asturias |
| Edison Electronics, S.L. | Barcelona |
| eDojo | Barcelona |
| EDP Energias de Portugal | Madrid |
| Eduardo Informática | Madrid |
| Educaria | Madrid |
| Educaverse | Sevilla |
| EdutechCluster | Barcelona |
| EENI Global Business School | |
| Efenet | A Coruña |
| EFI Data | Barcelona |