| Reveal Genomics, S.L. | Barcelona |
| Rever | |
| Revista Byte TI | Madrid |
| Revista Transformación Digital | Madrid |
| Revolution Software, S.L. | Alicante |
| RGB Informàtica i Consulting, S.L. | Lleida |
| RIB Software SE | Madrid |
| Ribera Salud, S.A.U. | Valencia |
| Ric Energy | Madrid |
| Ricard Menor | |
| Ricardo García Vega | Asturias |
| Ricopia Technologies, S.A. | Madrid |
| Riello Enerdata, S.L.U. | Madrid |
| Rifé Electrònica, S.A. | Barcelona |
| Rio Ancho Multimedia, S.L. | Barcelona |
| Risc Informàtica | Tarragona |
| Road To Data | Madrid |
| Rob Surgical | Barcelona |
| Roberto Romero | |
| ROBIT Sistemas Informaticos y Comunicaciones, S.L. | Madrid |
| Robot, S.A. | Balearic Islands |
| Robota | Madrid |
| Robotnik Automation, S.L. | Valencia |
| Robytec | Madrid |
| Rocket Studio | Madrid |
| Rokubun | Barcelona |
| Rokubun, S.L. | Barcelona |
| Roline System | Barcelona |
| Romo Telecomunicaciones, S.L. | Biscay |
| Rompal | Barcelona |
| Roomleader | Barcelona |
| RS Cloud Soluciones Tecnológicas, S.L. | Madrid |
| RSB Agency | Barcelona |
| RTM Solution Mantenimiento Informático | Madrid |
| Rural Servicios Informáticos, S.L. | Madrid |
| Rviewer | Barcelona |
| S&C Automatismos de Seguridad | Cádiz |
| S&M Services | Biscay |
| S.M.E. Instituto Nacional de Ciberseguridad de España M.P., S.A. | León |
| S2 Grupo | |
| S21Sec | Gipuzkoa |
| Sabadell Digital, S.A.U. | Barcelona |
| Sabadell Venture Capital | Barcelona |
| SADMedia | Madrid |
| Safeline, S.L. | Barcelona |
| Safeloc Systems, S.L. | Gipuzkoa |
| SAI Computers | Barcelona |
| Sale Systems | Madrid |
| Sales Layer | Valencia |
| Salvat | Barcelona |