| totSuma | Barcelona |
| Tradler | Barcelona |
| TrainingExperience, S.L. | Valencia |
| TramitApp, S.L. | Madrid |
| Transeop | Córdoba |
| Transferencia Bancaria PSD2 | Valencia |
| Tranxfer | Barcelona |
| Trappit | Madrid |
| Trazada Internet Marketing | Madrid |
| TreceBits | Madrid |
| Trend Robotics, S.L. | Santa Cruz de Tenerife |
| Trentia Consulting, S.L. | Barcelona |
| Tresce Digital Marketing Agency | Barcelona |
| Triditive | Asturias |
| Trimedia e-Consulting, S.L. | Madrid |
| Trinfo, S.L. | Huesca |
| Triodos Bank España | Madrid |
| Trioteca | Barcelona |
| Triple O Games | Santa Cruz de Tenerife |
| Triporate | Madrid |
| Triskell Software | Madrid |
| trueIT Systems, S.L. | Madrid |
| Trupp Publicidad | Biscay |
| Trusteam Capital, S.L. | Madrid |
| Trypton Software | Asturias |
| Tu Fábrica de Eventos | Madrid |
| Tu Posicionamiento Web | Madrid |
| Tucan Information Technologies, S.L. | Barcelona |
| Tucan IT, S.L. | Barcelona |
| tugesto | Valencia |
| TUNALKAN eBusiness, S.L. | Madrid |
| Turning Tables | Granada |
| Tus Documentos Online | Ciudad Real |
| TV Alper | Madrid |
| Twentic | Barcelona |
| Twinco Capital | Madrid |
| Twinco Capital M&O Spain, S.L. | Madrid |
| Tycsa PSC | Cantabria |
| Typeform | Barcelona |
| Tyris Software | Valencia |
| Tyris Tx | Valencia |
| U-tad | |
| UAV Navigation | Madrid |
| Ubik, S.L. | Madrid |
| Ubilibet by Nominalia | Barcelona |
| Ubiqum Code Academy | Barcelona |
| Ubiquotechs | Madrid |
| UBIS Servicios Informáticos | Biscay |
| Ubuntu-es | Castellón |
| uDA Real Estate Data, S.L. | Madrid |