| SilverXis, Inc. | |
| Silvon Software, Inc. | Illinois |
| SILVR | |
| Silvus Technologies | |
| SIM2K, Inc. | Indiana |
| Sima S. Enterprises, LLC | New Jersey |
| SiMa Technologies, Inc. | California |
| SIMBA Chain, Inc. | Indiana |
| SimBco | |
| Simbe Robotics, Inc. | California |
| Simbex | New Hampshire |
| SimBioSys | Illinois |
| SimBiotic Software for Teaching and Research, Inc. | New York |
| SimBlocks, LLC | Florida |
| Simbo, Inc. | Massachusetts |
| SimCare AI | |
| Simcha Therapeutics | |
| Simcoach Games | Pennsylvania |
| SimCrest, Inc. | Texas |
| Simdex, LLC | Wisconsin |
| SimDex, LLC | |
| Simergent | Oklahoma |
| Simetra Systems, Inc. | California |
| Simetrik, Inc. | |
| Simex Defence, Inc. | |
| Simform | Florida |
| SimGames.net | Illinois |
| Simgulary, LLC | |
| SimilarWeb Ltd | New York |
| Simio, LLC | Pennsylvania |
| Simle Thread | Virginia |
| Simma Software, Inc. | Indiana |
| simMachines, Inc. | Illinois |
| Simmer Creative, LLC | Pennsylvania |
| Simmons College of Kentucky | Kentucky |
| Simmons University | Massachusetts |
| Simmtec, Inc. | California |
| Simon Data | New York |
| Simon Says, Inc. | California |
| Simon Sez IT, LLC | Florida |
| Simon Systems | Minnesota |
| SimonComputing, Inc. | Virginia |
| SimoneSystems Software, LLC | Tennessee |
| Simons Laufer Mathematical Sciences Institute | |
| Simon’s Rock at Bard College | New York |
| SimoTime Technologies & Services | California |
| Simpalm | Maryland |
| Simpatra, Inc. | Arizona |
| Simpello, LLC | |
| SimPhonics, Inc. | Florida |