| SMDesign Studio | |
| SMDS | |
| SME Cloud | Wyoming |
| SMe Software, Inc. | Idaho |
| Smeisty Co. | Texas |
| SMG Pharmaceuticals | |
| SMGlobal, Inc. | North Carolina |
| Smile Dent | |
| Smile Global | Washington |
| Smile MEDIA, LLC | |
| Smile Outsourcing | Florida |
| Smile Virtual, LLC | |
| SmileML | |
| SmileOnMyMac, LLC | California |
| Smiley Antenna Co., Inc. | California |
| Smiley Technologies, Inc. | Arkansas |
| SmileyRose Web Solutions | Utah |
| Smiling Dog | Illinois |
| Smirk Interactive | |
| SMITH | Washington |
| Smith College Computer Science | Massachusetts |
| Smith College Mathematical Sciences | Massachusetts |
| Smith Commerce | |
| Smith Consulting | |
| Smith Health, Inc. | |
| Smith Kroeger | |
| Smith Marketing, Inc. | Illinois |
| Smith Micro Software | California |
| Smith Point Capital | |
| Smith+Nephew, Inc. | |
| Smith-Kettlewell Eye Research Institute | |
| Smith.ai, Inc. | California |
| SmithComputerParts.com | North Carolina |
| Smithers | |
| SmithGear | South Carolina |
| Smiths Interconnect | Kansas |
| Smithville Communications, Inc. | Indiana |
| SmithySoft, LLC | |
| Smitten, LLC | |
| Smitty's Holdings, Inc. | Florida |
| Smittyware.com, LLC | Georgia |
| SML RFID | Texas |
| SMOBIO Technology, Inc. | |
| Smodin, LLC | |
| Smokeball, Inc. | Illinois |
| Smoky City Design, LLC | Pennsylvania |
| Smooth Drug Development | Delaware |
| Smooth Fusion, Inc. | Texas |
| Smooth Rentals | |
| Smooth Solutions, Inc. | New Jersey |