| Serverreinigung | Berlin |
| service & media online-werbung GmbH | Schleswig-Holstein |
| Service für Sicherheitstechnik GmbH | Bavaria |
| Service Unlimited | Thuringia |
| service-system GmbH | |
| Serviceware SE | |
| ServiceZeit.com | Saxony |
| SERVOWATT Leistungselektronik GmbH | Baden-Württemberg |
| SES RFID GmbH | |
| SET – Software Engineering GmbH | Bavaria |
| Setis GmbH | Hesse |
| Setting HQ GmbH | |
| sevDesk GmbH | Baden-Württemberg |
| Seven Principles AG | North Rhine-Westphalia |
| Seven Senders GmbH | |
| Seven.One Entertainment Group GmbH | |
| SevenCs GmbH | Hamburg |
| SEVENSTAX GmbH | Lower Saxony |
| Seventythree Networks GmbH | Bavaria |
| SEWIGA Software - Team GmbH | Saarland |
| SEWTS GmbH | |
| Seyfcom | Lower Saxony |
| SF Software | Bavaria |
| SFC Software for Companies GmbH | Bavaria |
| sg websolutions | Bavaria |
| SG-Elotech GmbH | Thuringia |
| SGL Carbon | |
| SH Automation GmbH | Baden-Württemberg |
| SH business COM GmbH | Baden-Württemberg |
| SH Telekommunikation Deutschland GmbH | North Rhine-Westphalia |
| SH-Halbleiter Electronic Vertrieb GmbH | Bavaria |
| Shackspace | Baden-Württemberg |
| Shadow-Webdesign | North Rhine-Westphalia |
| SHAKEN not STIRRED Consulting GmbH & Co. KG | Hamburg |
| Shamrock Software GmbH | Bavaria |
| SHAPE | Baden-Württemberg |
| Sharework GmbH | Hamburg |
| Sharkbite Innovation GmbH | |
| Sharp Electronics (Europe) GmbH | North Rhine-Westphalia |
| Sharpist GmbH | |
| SHE Informationstechnologie AG | Rhineland-Palatinate |
| Sherpa Group GmbH | Bavaria |
| SHF Communication Technologies AG | Berlin |
| SHH Software GmbH | Hesse |
| shift GmbH | Hesse |
| shiftscreen | |
| Shin'en Multimedia GmbH | Bavaria |
| Shipcloud GmbH | |
| SHL AG | |
| shm Software GmbH & Co. KG | Bavaria |