| Declicweb | Paris |
| DeDAeLe Multimédia | Gard |
| Dedalus France | Drôme |
| Dedienne Aerospace | |
| Deemea S.A.S. | |
| Deep Silver | Seine-Saint-Denis |
| Deepki | Paris |
| Deeplink Medical | |
| Deepomatic S.A.S. | |
| DeepOR | Paris |
| DeepTalk | |
| Déessi | |
| Defacto | |
| Défense Datacenter | Hauts-de-Seine |
| Defensive Lab Agency S.A.S. | Paris |
| Defi Web Design | Moselle |
| Degetel | Hauts-de-Seine |
| Degriffmac | Paris |
| Deho Systems | Val-de-Marne |
| DEiiS | Val-d'Oise |
| Delair | |
| Delaware Consulting S.A.S. | |
| DELETEC | Paris |
| Delf | Paris |
| Délibérata | Seine-Maritime |
| DeliCAD | Puy-de-Dôme |
| Delice Robotics | |
| Delight | |
| Deliver.ee | |
| Delixir | Loiret |
| Delpharm | |
| DELSSI | Nord |
| Delta Flash | Bouches-du-Rhône |
| Deltamu | Puy-de-Dôme |
| Deltest S.A.R.L. | Meurthe-et-Moselle |
| DEMLOG S.A.R.L. | Nord |
| Demooz Processing | |
| Dendreo | Paris |
| Denis Billo | Var |
| Denis Lallement | Morbihan |
| Dental Monitoring | |
| Depaepe S.A.S. | Val-d'Oise |
| Depannaid PC | Loiret |
| Depannpc64 | Pyrénées-Atlantiques |
| Depixus | |
| Derichebourg Aeronautics Training | |
| DESA Logiciels | Yvelines |
| Descartes Underwriting | |
| Design'Partner | Calvados |
| Désirade | Haute-Garonne |