| EirGen Pharma | |
| Eirhost Web Hosting Ireland | Dublin City Council |
| Eirtech Aviation Services | |
| Eirtight Technology | Dublin City Council |
| EKCO | |
| Elara Online Ireland | Dublin City Council |
| Electronic Trade Solutions Ltd | Dublin City Council |
| Element78 | |
| Elestio | |
| Elive | Limerick City and County Council |
| Emagine | |
| Emarkable | Dublin City Council |
| EMR Integrated Solutions | |
| Encad Software | Dún Laoghaire-Rathdown County Council |
| Encom Systems Ltd | Dublin City Council |
| Enet | |
| Engine Lab Software | Dublin City Council |
| Engine Solutions | Dublin City Council |
| Enhance.ie | Fingal County Council |
| Enovation | Dublin City Council |
| Enterprise Equity Venture Capital | |
| Enterprise Ireland | |
| Environet Solutions | |
| ePresence | Cork City Council |
| Equisoft DAC | Kildare County Council |
| Ergo | |
| ERS | Dublin City Council |
| ERS Genomics | |
| ESET Ireland | Wexford County Council |
| essCert | |
| EssentialSkillz | |
| ETU | |
| EU-XCEL | Cork City Council |
| Eurieka IT Services Ltd | Dublin City Council |
| European Hosting Solutions | Dublin City Council |
| Eurosoft | South Dublin County Council |
| Eventznet Ltd | |
| Evercam | |
| Everseen Ltd | |
| EVERYANGLE | |
| EVERYANGLE | |
| Everything IT | Dublin City Council |
| Evolution Digital | |
| Ex Ordo | Galway City Council |
| Exertis Ireland | Dublin City Council |
| Exigent Networks Integration Ltd | Cork City Council |
| eXpd8 Ltd | Fingal County Council |
| eZee Software | |
| Farmflo | Cork City Council |
| Farran Technology Ltd | Cork City Council |