| Supply Finance | |
| SureSkills Ltd | |
| Swappsi Ltd | |
| Sweepr Technologies Ltd | |
| Swift Web | Dublin City Council |
| Swiftcall | Dublin City Council |
| Switch Business Systems | |
| Symberity | Cork City Council |
| SymPhysis Medical | |
| Synergy Centre ITT Dublin | Dublin City Council |
| SynOx Therapeutics Ltd | |
| Sysco Ireland | |
| Sysco Software Solutions | Dublin City Council |
| Systeme.io | |
| Systems Modelling Ltd | Wexford County Council |
| Sysxnet Ltd | Dublin City Council |
| TADCO Apps Ltd | |
| TalentHub | |
| Talkpush | |
| Talmatic | |
| Taoglas | Wexford County Council |
| Tapadoo | |
| Target Integration | |
| TASC | Dublin City Council |
| Taxback | |
| Teach 'n Go | |
| Teagasc | |
| Teamwork.com Ltd | Cork City Council |
| Tech Life Ireland | Dublin City Council |
| Tech Skills | |
| Tech Unit | |
| Tech Week | Dublin City Council |
| TechCentral.ie | Dublin City Council |
| TechIreland | Dublin City Council |
| TechMeetup.Space | |
| Technological University Dublin | |
| Technology Gateway Network | |
| Techstore | Kildare County Council |
| TEJ | |
| Ten10 | |
| Tenego Partnering | Cork City Council |
| Terenure Enterprise Centre | |
| TerminusDB | |
| Tesco Mobile | Dublin City Council |
| Test Triangle | |
| Testimonial Robot | |
| Tetra Technology | |
| The Coder Spot | |
| The DataWorks | |
| The Design Hub | |