| Invest in Lombardy | Milan |
| INVRSION S.r.l. | |
| Inweb Adriatico S.r.l. | Pescara |
| Inxpect S.p.A. | |
| InYourLife S.r.l. | Florence |
| iPhoneAssistRoma | Rome |
| iPhoneHospital | Turin |
| IPKom S.r.l. | Arezzo |
| IPnext S.r.l. | Milan |
| Iprogrammatori S.r.l. | Milan |
| IPSA S.r.l. | |
| Ipses S.r.l. | Milan |
| Ipsnet | Turin |
| iQuad | Varese |
| IRBM S.p.A. | |
| IRCE S.p.A. | Bologna |
| IRETH | Turin |
| IRIDEOS S.p.A. | Milan |
| IrisNet Solutions | Pisa |
| Irpinia Linux User Groups | Avellino |
| Irriworks S.r.l. | Palermo |
| IRS International Recovery Service | Friuli-Venezia Giulia |
| ISAAC S.r.l. | |
| Ischia Web Software | Naples |
| ISI Foundation | Turin |
| Isicom S.r.l. | Modena |
| Isiweb S.r.l. | Monza and Brianza |
| Iso Sistemi S.r.l. | Genoa |
| iStarter S.p.A. | |
| Istella S.p.A. | |
| Istella S.r.l. | Cagliari |
| Istituto IDI Informatica | Florence |
| Istituto Italiano di Tecnologia | Genoa |
| Istituto Nazionale Biostrutture e Biosistemi - Consorzio Interuniversitario | |
| Istituto Nazionale di Ottica | Florence |
| It Consult | Pesaro and Urbino |
| IT Project S.r.l. | Brescia |
| It's Prodigy | Milan |
| It's S.r.l. | Brescia |
| IT.Gate S.p.A. | Turin |
| Itac Tron S.r.l. | Rome |
| Ital Innovation | Macerata |
| Italcom S.p.A. | Alessandria |
| Italfarmaco S.p.A. | |
| Italia Innovation S.r.l. | |
| Italian Angels for Biotech | Milan |
| Italian Angels for Growth | Milan |
| Italian Food Tech | Milan |
| Italian Tech | Turin |
| Italian Tech Academy | Milan |