| Yakkyo S.p.A. | Rome |
| Yape S.r.l. | Milan |
| Yarix S.r.l. | Treviso |
| Yocabè S.r.l. | Rome |
| YOMI | Milan |
| Yoroi S.r.l. | |
| YoRoom | Milan |
| You Can Group | Bologna |
| You Com S.r.l. | Friuli-Venezia Giulia |
| You-Can.it | Macerata |
| Young Platform S.p.A. | |
| YourBiz S.r.l. | Bergamo |
| Youtoo Digital S.r.l. | Milan |
| YumeStudio.it | Padua |
| Z3 Engineering | Chieti |
| Zakeke | |
| Zambon Company S.p.A. | |
| Zancan Technology | Padua |
| Zancoa.it | Treviso |
| ZapTech | Trento |
| Zaval Creative Engineering Group | Trento |
| Zefi ai | |
| Zero S.r.l. | Milan |
| Zeroundo S.r.l. | Milan |
| ZeroUno | Milan |
| ZeroZeroSEO | Milan |
| Zerynth S.p.A. | |
| Zetaelle S.r.l. | Venice |
| Zik Software | Turin |
| ZioSEM S.r.l. | Turin |
| Zip Computer S.r.l. | Milan |
| Zirak S.r.l. | Cuneo |
| Zoe Web Agency | Bologna |
| Zona Zero S.n.c. | Florence |
| Zucchetti | Lodi |
| Zucchetti AXESS S.p.A. | Lodi |
| Zucchetti Centro Sistemi S.p.A. | |
| Zucchetti S.p.A. | Lodi |
| Zucchetti Software Giuridico S.r.l. | Vicenza |
| Zuffellato Computers S.r.l. | Ferrara |
| ZuluWeb | Turin |
| Zumedia | Florence |