| Rewido | |
| RewiSoft | |
| RHO Software | Lesser Poland |
| Right Information | |
| Ringier Axel Springer Polska Sp. z o.o. | |
| RITS Professional Services Sp. z o.o. | Masovian |
| Robotec.ai Sp. z o.o. | |
| Robotyka.com | Lesser Poland |
| Rocket Jobs | |
| Rockon Sp. z o.o. | Masovian |
| Rocks & Gold | |
| Roger Sp. z o.o. Sp. k. | Pomeranian |
| RolTech | Opole |
| Roud Studio | Masovian |
| RSI | Silesian |
| RST LIFT-OFF Startup Accelerator | |
| RST Software Masters | Lower Silesian |
| RST Ventures For Earth Sp. z o.o. | |
| Ruby Logic | Silesian |
| Rumble Fish | Lesser Poland |
| Rybnet | Silesian |
| Ryvu Therapeutics | Lesser Poland |
| S 90 | Silesian |
| S&P Partners | |
| S&T | Masovian |
| S-Labs | |
| S-NET Sp. z o.o. | Lesser Poland |
| S.O.S. P.M. Wesołowscy | Kuyavian-Pomeranian |
| S4E S.A. | |
| SaaS Native Sp. z o.o. | |
| SABUR Sp. z.o.o. | Masovian |
| Sacer S.C. | Pomeranian |
| Safebox24 | |
| SaferInternet | Masovian |
| SafiStudio | |
| Sages Sp. z o.o. | Masovian |
| Sagiton | |
| Saleor | |
| SALESmanago | |
| SALESmanago | |
| Samito S.A. | |
| Samsung Electronics Polska Sp. z o.o. | Masovian |
| Sanmar Sp. z o.o. | |
| Santander Bank Polska S.A. | Masovian |
| Santander Consumer Bank Polska | |
| SATIM | |
| SatRev | |
| Satus | |
| Satus Venture Sp. z o.o. | Lesser Poland |
| Saule Technologies | |