| Softwizard | |
| Softworks | Masovian |
| Soho Development S.A. | |
| Sokrates Software | Masovian |
| Solar Innovation | |
| Sold App Sp. z o.o. | |
| Solid Security | |
| Solidexpert Polska Sp. z o.o. Sp. k. | Lesser Poland |
| Solidstudio | |
| Sology | Lesser Poland |
| Solution.pl | |
| Solwena Sp. z o.o. | |
| SonarHome S.A. | |
| SONET | Masovian |
| Sony Europe Ltd (Sp. z o.o.) | Masovian |
| SOTE | Greater Poland |
| Sotrender | |
| SP Tech Solutions | |
| Space3ac | |
| SpaceAdventure | Masovian |
| SpaceFactory CE Sp. z o.o. sp.k. | |
| spaceOS Ltd | |
| Spark-Tech Sp. z o.o. | |
| Sparkbit | |
| Spartańska | |
| Specctrum | Subcarpathian |
| Spectator Sp. z o.o. | Lesser Poland |
| SpeedApp Sp. z o.o. | Masovian |
| Speednet Sp. z o.o. | |
| SpeedUp Venture Capital Group | Greater Poland |
| Spica Solutions | |
| Spinney | |
| Spire Capital Partners | |
| Sportdata Serwis Sp. z o.o. | |
| Spółdzielcza Grupa Bankowa | |
| Spółdzielnia Telekomunikacyjna OST | |
| Spółka Inżynierów SIM | Lublin |
| Sprint S.A. | Warmian-Masurian |
| Sprinter IT Sp. z o.o. | Opole |
| Sputnik Software Sp. z o.o. | Greater Poland |
| Spyrosoft BSG | |
| Spyrosoft S.A. | Lower Silesian |
| SpyShelter | Lesser Poland |
| SSI - Agencja Interaktywna | West Pomeranian |
| sStore | Silesian |
| SSW Pragmatic Solutions | |
| Stabilis | |
| Standard Polish Enterprise SPE IMEX Sp. z o.o. | Łódź |
| Star Telecom Sp. z o.o. | Lublin |
| Starfax Polska Sp. z o.o. | Masovian |