| Sure-Track Europe Ltd | Warwickshire |
| sureCore Ltd | |
| Surefire Print & Design | |
| Suretec Systems | Aberdeen |
| Surface Impression | |
| Surface Science Software Excellence | Kent |
| Surfboard Technology Ltd | |
| Surfing Penguin | |
| Surftec Ltd | Surrey |
| Surge | |
| Surges | |
| Surreal Vision Ltd | |
| SurrealDB Ltd | |
| Surrey NanoSystems Ltd | |
| Surrey Research Park | Surrey |
| Surrey Satellite Technology Ltd | Surrey |
| Survey Galaxy Ltd | |
| Sushi Venture Partners | Greater London |
| Sussex Community Internet Project | East Sussex |
| Sussex Designs | East Sussex |
| Sussex Mac Users' Group | East Sussex |
| Sussex PC Repair | East Sussex |
| Sussex Place Ventures Ltd | |
| Sussex SEO Ltd | East Sussex |
| Sussex Solutions | East Sussex |
| Sustainable Ventures | |
| Sustainable Web Solutions | Greater Manchester |
| SV Health Investors, LLP | |
| Svek Computing Ktd | Gloucestershire |
| SVEK Computing Web Hosting | Carmarthenshire |
| SVP.co.uk | Clackmannanshire |
| Swaisland Ltd | Berkshire |
| SwallowGames | Norfolk |
| SwankyApple Ltd | Devon |
| Swanley Computers | Kent |
| Swansea ITeC | Swansea |
| Swansea University | Swansea |
| Swansea University - Department of Computer Science | Swansea |
| Swansea University - Mathematics | Swansea |
| Swansoft Ltd | Channel Islands |
| Swap Commerce Ltd | |
| Swapi Ltd | |
| Swarm Oncology | |
| Sweans Technologies Ltd | |
| Sweatcoin | Greater London |
| Sweet Apple Technical Support | Wiltshire |
| Sweet Chilli Media | Cornwall |
| Sweet Marketing | |
| Sweetbridge Ltd | |
| Sweethaven Computers | Surrey |