| Edot Web Technologies | Gauteng |
| Ehlanzeni TVET College | |
| Ehost | Western Cape |
| Ekurhuleni West Technical, Vocational, Education and Training College | |
| Elancergroups (Pty) Ltd | Gauteng |
| Electric Sheep Agency | Western Cape |
| Electric Sheep Agency | |
| Electro Designs | Gauteng |
| Electro Tech Solutions (Pty) Ltd | Gauteng |
| Electronic Ideas | KwaZulu-Natal |
| Electronic Service Centre CC | Gauteng |
| Electronics Incorporated | KwaZulu-Natal |
| Electronics123 | Gauteng |
| Electrum Payments | Western Cape |
| Electrum Payments | |
| Elegant Works Consulting (Pty) Ltd | Gauteng |
| Elemental | Western Cape |
| Elemental Studios CC | Western Cape |
| Elevate Internet Marketing | Gauteng |
| Elevation Design | Western Cape |
| Elite Ideas | Free State |
| Elite Mobile | KwaZulu-Natal |
| Elitehost | Gauteng |
| EliteWeb | Western Cape |
| Ellipsys Group | Gauteng |
| ElmMac (Pty) Ltd | KwaZulu-Natal |
| Elnatan Technologies | Gauteng |
| eMD | Gauteng |
| emediaIT | Eastern Cape |
| Emerge Customer Flow Management (Pty) Ltd | Gauteng |
| Encoresolutions | Gauteng |
| Energia Corporate Solutions (Pty) Ltd | Gauteng |
| Enerweb (Pty) Ltd | Gauteng |
| eNetworks | Western Cape |
| Enfin Energy Finance | |
| Enigma Designs | Gauteng |
| Entegral Technologies (Pty) Ltd | Gauteng |
| Enterprise Outsourcing | Gauteng |
| Envisionit Deep AI (Pty) Ltd | Gauteng |
| Enyuka.com | Gauteng |
| EOH | Gauteng |
| Eons Digital | |
| eProfile | Gauteng |
| Equadoor Web Design & Marketing Services | Limpopo |
| Equation Business Solutions | Western Cape |
| ERC Design | |
| ERS Biometrics | Gauteng |
| eSG Networks | Gauteng |
| Espero Computer Systems | Gauteng |
| Esquire Technologies | Gauteng |