| ESRI South Africa | Western Cape |
| Essential IT Solutions | Western Cape |
| Estar web design | Western Cape |
| eStart Computer Services CC | Gauteng |
| Estuary Solutions | Western Cape |
| eta College | |
| Etraffic | Gauteng |
| eTX Data Services | KwaZulu-Natal |
| Euphoria Software | Gauteng |
| Euphoria Telecom (Pty) Ltd | Western Cape |
| EuroByte Online | Gauteng |
| Eurotel | Western Cape |
| Evaluate Assessment Solutions (Pty) Ltd | Gauteng |
| EvaluNet | Western Cape |
| Evan Ross | |
| EvenFlow | Western Cape |
| Ever Dgitial Marketing | Gauteng |
| Everett Computer Consultantd | Gauteng |
| Everlytic | Gauteng |
| Evo-V (Pty) Ltd | |
| Evolving Management Solutions | Gauteng |
| Exalon Dynamic Systems | KwaZulu-Natal |
| Excel-Skills.com | Western Cape |
| Exclaim Innovations | Gauteng |
| Exclusive Web Design | KwaZulu-Natal |
| Execmail IT Solutions | Gauteng |
| Face Technologies | Gauteng |
| FailSafe Systems | KwaZulu-Natal |
| Falcon Electronics (Pty) Ltd | Gauteng |
| FAQ (Pty) Ltd | Western Cape |
| Faranani | Gauteng |
| FastSite | Gauteng |
| FDCS | Gauteng |
| FDesign | Western Cape |
| FGX Studios | Gauteng |
| Fibretronics Sales (Pty) Ltd | Eastern Cape |
| Financial Sector Conduct Authority | |
| Finbond Mutual Bank | |
| FinChatBot | Gauteng |
| Fincheck.co.za | |
| FinComp Technologies | Gauteng |
| Finstone Information Technologies (Pty) Ltd | Gauteng |
| Fir3storm Technology | |
| Firewater Interactive | Gauteng |
| Fireworkx | Western Cape |
| First Coast Technologies | Western Cape |
| First Distribution | Western Cape |
| First Technology | Free State |
| FirstNet | KwaZulu-Natal |
| FirstRand | |