| StokFella (Pty) Ltd | |
| Storm Business Solutions | Gauteng |
| StormBiz | Gauteng |
| Stormtech | Western Cape |
| Stouf Communications | Gauteng |
| Strang IT Consulting | Gauteng |
| Stratahost | |
| Strategic Online Marketing Services (Pty) Ltd | Gauteng |
| StrategyOnline | Western Cape |
| Streamnet Internet Solutions | KwaZulu-Natal |
| Strider | Gauteng |
| Studio 29 | Western Cape |
| Studio256 | Gauteng |
| Sulaco New Media (Pty) Ltd | Gauteng |
| Summit Networks | Gauteng |
| Suneldo | Northern Cape |
| Supima Technologies | Gauteng |
| SurfStats | Gauteng |
| Surpac | North West |
| Sw7 | Gauteng |
| SWART | |
| SwiftCom | Gauteng |
| SwiftCom (Pty) Ltd | Western Cape |
| Switch Telecom | Gauteng |
| SybaWeb | Western Cape |
| Sybu Data | Western Cape |
| Symbioses Technology Solutions | Gauteng |
| Symbiote Web Development | |
| Symphony Systems | Western Cape |
| Synaq | Gauteng |
| Synch.cc | Western Cape |
| Synchramed (Pty) Ltd | Gauteng |
| Syncrony Digital | Gauteng |
| SynnCom CC | Gauteng |
| Syrinx Communications | Gauteng |
| Sys-Guru | Gauteng |
| Syscom | Western Cape |
| Systech Computing | Eastern Cape |
| System 5 | Gauteng |
| SystemicLogic | Gauteng |
| SyteDigital | Gauteng |
| SyteDigital | |
| Syzygy SEO | Gauteng |
| T-Grafix Graphic & Web Design | |
| T-Host-T | Gauteng |
| Tactile Technologies | Western Cape |
| Takealot.com | Western Cape |
| TalkWithUs Group | Western Cape |
| Tandem Create | |
| Tarsus On Demand | |