| Savian | |
| Savoir-faire Linux | Quebec |
| Savormetrics | |
| Savvy Search Marketing Ltd | British Columbia |
| Savvy Tech Computer Consulting | Saskatchewan |
| Savvyy Technologies, Inc. | |
| Say Yeah! | Ontario |
| SB Software, Inc. | |
| SBDCLOUD | |
| SBK Techno | Quebec |
| SBK Telecom | Quebec |
| SBM | Quebec |
| SBM Tech | Nova Scotia |
| SBQuantum | Quebec |
| SC2i.ca | |
| SC3 Automation, Inc. | Quebec |
| SC360 | Quebec |
| Scadax Automation Corporation | British Columbia |
| Scalar Software | Ontario |
| Scale AI | Quebec |
| Scale Up Atlantic Canada | |
| ScaleGood Fund, L.P. | |
| ScaleHR | |
| ScalePad, Inc. | |
| ScaleUP Ventures | |
| ScaleUp42 | |
| Scandia ISP Internet, Inc. | Ontario |
| Scanlab Photogrammetry, Inc. | |
| Scannabar | Quebec |
| ScanTech eForms Corporation | British Columbia |
| Scantranx | |
| Scapes | Alberta |
| Scarsin Corporation | Ontario |
| SCC Computers | Ontario |
| SCCI Technology Ltd | Quebec |
| SCDS Corporation | Quebec |
| Scelta | Ontario |
| Sceptre Communications, Inc. | Alberta |
| Schedule Masters, Inc. | Ontario |
| ScheduleCare | New Brunswick |
| SchemaZone | |
| Schif And The City | |
| SchoolBundle | Ontario |
| SchoolFinder | Ontario |
| Schroeder & Schroeder, Inc. | Ontario |
| Schultz Computer Network Systems Ltd | Ontario |
| SCI | |
| SCI Marketview | Ontario |
| SCiAN Services, Inc. | |
| Scidel Technologies, Inc. | Quebec |