| Skysoft Systems | Indiana |
| Skysoft, Inc. | Florida |
| SkySpecs | Michigan |
| SkySQL | |
| SkySwitch | |
| Skytap, Inc. | Washington |
| SkyTech Mobile | |
| SKYTEK Solutions, LLC | |
| SkyTerra | New Hampshire |
| SkyTide | |
| Skytop Software | Maine |
| SkyTouch Solutions, LLC | Arizona |
| Skytron, LLC | Michigan |
| SkyTrust, Inc. | |
| Skyview Advertising | |
| SkyView Technology | Illinois |
| Skyview Ventures | |
| SkyVu, Inc. | Nebraska |
| Skyward, Inc. | Wisconsin |
| Skyware Hospitality Solutions | Florida |
| SkyWatch Insurance Services, Inc. | California |
| Skywater Technology | Minnesota |
| Skywaves, LLC | Massachusetts |
| Skyway Media | |
| Skyways Air Transportation, Inc. | Texas |
| Skyways Air Transportation, Inc. | |
| Skyweb Networks, Inc. | Michigan |
| Skywire | New York |
| Skywiz Internet Services | New York |
| Skyword, Inc. | Massachusetts |
| Skyworker, Inc. | |
| Skyworks | Massachusetts |
| SkyWorld Interactive | Massachusetts |
| SL Power Electronics Corporation | California |
| Slabb Kiosks | Arizona |
| SLAC National Accelerator Laboratory | California |
| Slack Technologies, Inc. | California |
| Slade Systems | California |
| Slalom, Inc. | Washington |
| SLAM Biotherapeutics | |
| SLAM Solutions, Inc. | Nevada |
| Slamdot, Inc. | Tennessee |
| Slanecon Digital, Inc. | California |
| Slang | |
| Slash Financial, Inc. | California |
| Slash Pine Tech | |
| Slashdev | |
| Slashdot | California |
| SlashHash | |
| SlashNext, Inc. | California |