| Slate Capital Group | Maryland |
| Slate Digital, Inc. | |
| Slate Studio, Inc. | |
| Slate Tech | |
| Slater Technology Fund | Rhode Island |
| Slauson & Co. | |
| SLB | Texas |
| Sledgehammer Games | California |
| Sleeping Giant Studios | Wisconsin |
| Sleepless Media | California |
| Sleepless Software, Inc. | Washington |
| Sleight Advertising, Inc. | |
| Sleight-of-Hand Studios, LLC | Virginia |
| Slemma | |
| SLI Systems | California |
| Slice Insurance Technologies, Inc. | New York |
| Slice Solutions, Inc. | |
| Slice Works | |
| Sliced Bread | California |
| Slicer Dicer | Washington |
| SLICFiber | New York |
| Slick | |
| Slick Boston Solutions | |
| Slick Development, LLC | Washington |
| Slick Systems, LLC | Pennsylvania |
| SlickEdit | North Carolina |
| Slickplan | Ohio |
| SlickRockWeb, Inc. | Colorado |
| SlickText | New York |
| Slide | |
| Slide SJS | |
| Slidebean, Inc. | New York |
| SlideFactory, LLC | |
| SlideGenius | |
| Sliderule | California |
| Slides, Inc. | New York |
| SlideShare | California |
| SlidesPilot | |
| SlideTeam | New York |
| Sligo Software | |
| SliiceXR | Nevada |
| Slim Marty | |
| Slim Marty | |
| SlimBrowser | Texas |
| SlimWare Utilities Holdings, Inc. | New York |
| Sling Therapeutics | |
| Slingr | Colorado |
| Slingshot | Kentucky |
| Slingshot Aerospace | |
| Slingshot Aerospace | Texas |