| ENE | Métropole de Lyon |
| Enedis | |
| ENENSYS Technologies | Ille-et-Vilaine |
| Enerbee Technology | |
| Enerdigit | |
| Enerfip | |
| Energic | |
| Enero | Paris |
| ENERPLAN | Bouches-du-Rhône |
| ENEWS | Paris |
| Enez Solutions | |
| Engenius-Distribution S.A.S. | Paris |
| Engie | |
| Engie New Ventures | |
| ENI École Informatique | Loire-Atlantique |
| ENI Service | Loire-Atlantique |
| eNiX | Paris |
| Enjin S.A.R.L. | Maine-et-Loire |
| Enko | Ille-et-Vilaine |
| EnnoDC | |
| Ennov | |
| Ennovate Pharma | |
| Enodia Therapeutics | |
| Enovacom | Bouches-du-Rhône |
| Enovos | |
| ENS de Lyon - Laboratoire de l'Informatique du Parallélisme | Métropole de Lyon |
| ENS Rennes | |
| ENSAE Paris | |
| ENSAI | |
| Ensembl’ | |
| ENSIIE | Essonne |
| Ensol Group S.A.S. | |
| ENSTA Paris | |
| ENT System | Paris |
| Enterome | |
| Enterosys | |
| Entities | |
| Entr'ouvert | Paris |
| Entrecom Social | Loire-Atlantique |
| Entrepreneur Invest | |
| Entropics | Métropole de Lyon |
| ENYO Pharma S.A. | |
| Eolane | Maine-et-Loire |
| Eolas | Isère |
| Eolica | Gard |
| Éolie S.A.R.L. | |
| eOMS | Alpes-Maritimes |
| EOS France | |
| EOS Imaging | |
| Eoxia | Hérault |