| Elliogen | |
| Ellona | |
| Eloquant | Isère |
| ELP - Edition de Logiciels Professionnels | Paris |
| Elpack | Drôme |
| Elseware | Paris |
| Elum Energy | |
| ELVIA Printed Circuit Boards | Manche |
| Elwin | |
| Elyas Conseil | |
| Elyazalée | Côtes-d'Armor |
| Elyn | |
| Elyse Energy | |
| EM Lyon Business School | |
| EM Normandie Business School | |
| EM Strasbourg Business School | |
| Emaginair | Doubs |
| eMaginance | Alpes-Maritimes |
| EMAsphere | |
| EMBA Business School | |
| Emeka | |
| Emencia | Paris |
| Emeraude Escape | |
| Emercell | |
| Emerging Valley | Bouches-du-Rhône |
| Emersya | |
| Emglev Therapeutics | |
| Emil | |
| Emissive | |
| EMIT | Moselle |
| Emjysoft | Drôme |
| Emka Électronique | |
| Emma | Vaucluse |
| Emmanuel GIBOUR | Indre-et-Loire |
| Emosis Diagnostics | |
| EMOTIC | |
| Emoxa | |
| Empirik | |
| Empreinte | Paris |
| Empreinte Digitale | Maine-et-Loire |
| Emulseo | |
| En Carta Diagnostics | |
| ENACO | |
| Enchanted Tools | |
| Enciris Technologies S.A.S. | Tarn |
| Encre Sepia | Pyrénées-Atlantiques |
| Encre.com | Val-de-Marne |
| Endodiag | |
| Endogene.Bio | |
| Endrix | |