| Ensembl’ | |
| ENSIIE | Essonne |
| Ensol Group S.A.S. | |
| ENSTA Paris | |
| ENT System | Paris |
| Enterome | |
| Enterosys | |
| Entities | |
| Entr'ouvert | Paris |
| Entrecom Social | Loire-Atlantique |
| Entrepreneur Invest | |
| Entropics | Métropole de Lyon |
| ENYO Pharma S.A. | |
| Eolane | Maine-et-Loire |
| Eolas | Isère |
| Eolica | Gard |
| Éolie S.A.R.L. | |
| eOMS | Alpes-Maritimes |
| EOS France | |
| EOS Imaging | |
| Eoxia | Hérault |
| EP | Loire-Atlantique |
| EPHI Informatique Électronique | Meuse |
| Episkin | |
| Episoft | Hauts-de-Seine |
| Epistrophe | Yvelines |
| Epitech | |
| EPIXELIC | Val-de-Marne |
| ePro Shopping | |
| EprocFactory | |
| EPSILON Informatique | Morbihan |
| Epsilyon | Métropole de Lyon |
| Epson France | Hauts-de-Seine |
| Epsor | |
| Eptimum | Hauts-de-Seine |
| Equasys | Tarn |
| Equation | Loire |
| Equi-Conseil | Essonne |
| Equinoxes | Aisne |
| Équipages IT Solutions | |
| Equipements Scientifiques S.A. | Hauts-de-Seine |
| ER Telecom | Seine-et-Marne |
| Eralabs | |
| ERAZ | Rhône |
| Ercogener | Maine-et-Loire |
| ERCOM | Yvelines |
| ERELIA Informatique et Pesage | Essonne |
| Erems | Haute-Garonne |
| Ergole Informatique | Isère |
| ÉRIC France | Hauts-de-Seine |