| Consea S.r.l. | Milan |
| Consiglio Nazionale delle Ricerche | Rome |
| Consisto GmbH | South Tyrol |
| Consoft Sistemi S.p.A. | Turin |
| Consorzio Netcomm | Milan |
| Consult S.r.l. | Milan |
| Consys.IT S.r.l. | Milan |
| ContactLab S.p.A. | |
| Contents S.p.A. | |
| Contrel Elettronica S.r.l. | Lodi |
| Contrive S.r.l. | Bergamo |
| Controltec S.r.l. | Varese |
| Convel S.r.l. | Monza and Brianza |
| Cool Web Agency S.r.l. | Salerno |
| Coolrs S.r.l. | |
| Cooperativa GE.A.T. | Alessandria |
| Coopstartup | Rome |
| Copernico | |
| Copnsumer S.p.A. | Milan |
| Coresis S.r.l. | Como |
| CoreView | Milan |
| Coriweb S.r.l. | Bergamo |
| Cosmico S.r.l. | |
| Cosmodesign | Bari |
| Cosmosel | Como |
| CoST - Computers Services and Technologies S.r.l. | Milan |
| Cotini S.r.l. | Milan |
| Coveronweb S.r.l. | Milan |
| Coverzen S.r.l. | |
| Coworking Login | Milan |
| Coworking Milano Biocca | Milan |
| Coworking Spazio 14 | Bari |
| CP S.p.A. | Modena |
| CREA - Collaudi Elettronici Automatizzati S.r.l. | Turin |
| Crea Solution | Bologna |
| Crea Summer Academy | Milan |
| Creative Solutions Engineering | Treviso |
| Crédit Agricole Italia S.p.A. | |
| CrescItalia Servizi Imprese S.r.l. | |
| CrestOptics S.p.A. | |
| Crimson Byte | Perugia |
| Crionet World | Naples |
| CRMpartners S.r.l. | |
| CROMSOURCE | Verona |
| Cronosmedia S.a.s. | Padua |
| Crowd2Be | Milan |
| CrowdFundMe S.p.A. | |
| CRP Technology S.r.l. | Modena |
| CryptoStars | Milan |
| CSI Piermonte | Turin |