| Derga Consulting S.r.l. | South Tyrol |
| Design.it | Milan |
| Designpro | Rome |
| DesoTech | Bari |
| Dev House | |
| devACADEMY | Turin |
| devAPP S.r.l. | Turin |
| devDept Software S.r.l. | Bologna |
| Develer S.r.l. | Florence |
| Develhope S.r.l. | |
| DevKit S.r.l. | Rome |
| Df Medica OOne S.r.l. | Bergamo |
| DFLABS S.p.A. | Milan |
| DG point | Milan |
| dgNet S.r.l. | Florence |
| DGS S.p.A. | Rome |
| DHH S.p.A. | |
| Diadem S.r.l. | Milan |
| Diaman Tech S.r.l. | |
| Diamante Società Benefit S.r.l. | |
| Dias S.r.l. | Milan |
| DiaSorin S.p.A. | |
| DiaSorin S.p.A. | |
| Diatech Pharmacogenetics S.r.l. | |
| Diatheva S.r.l. | |
| Dicoel S.r.l. | Milan |
| Diellesse | Messina |
| Difnet S.r.l.s. | Rome |
| DIGICOLOR.NET S.r.l. | Cremona |
| Digimetrica | Pescara |
| Digiphy, LLC | |
| Digisky S.r.l. | |
| Digit.ale | Pesaro and Urbino |
| Digitag Consulting | Milan |
| Digital 2b S.n.c. | Trapani |
| Digital Age S.r.l. | Rome |
| Digital Art & Manufacturing Academy | Milan |
| Digital Idea | Florence |
| Digital Magics | Milan |
| Digital Mosaik | Trento |
| Digital Sparks S.r.l. | |
| Digital Technologies | Milan |
| Digital Telco S.r.l. | Bari |
| Digital Valdamo | Arezzo |
| Digital360 S.p.A. | |
| Digital4 | Milan |
| DigitalFingers | Rome |
| DIGITALmeet | Padua |
| Digitazon Tech School | Milan |
| DigiTouch S.p.A. | |