| Progetto Archimede | Syracuse |
| Progetto Studio | Brescia |
| Progetto Uno S.r.l. | Padua |
| Progetto9 | Pesaro and Urbino |
| Proietti Tech S.r.l. | Ascoli Piceno |
| Project Automation S.p.A. | Monza and Brianza |
| Project Informatica S.r.l. | Bergamo |
| Project Informatica S.r.l. | |
| Projest S.p.A. | Prato |
| Promedias S.r.l. | Milan |
| Promelit S.p.A. | Milan |
| Prometeo S.p.A. | Rome |
| Prometeo-Lab | Rome |
| Promosecurity S.r.l. | Milan |
| Promotion Digitale | Lecco |
| Protec S.n.c. | Padua |
| Proxima Online S.r.l. | Naples |
| PSWEB | Milan |
| PTF Elettronica S.r.l. | Bologna |
| PTP Science Park | Lodi |
| PubCoder | Turin |
| Puecher | South Tyrol |
| PugliaStartup | Bari |
| Pulsar Engineering | Milan |
| Punto Informatico | Rome |
| Puntoexe Informatica | Bologna |
| PuntoWeb.Net S.a.s. | Pisa |
| Pushapp S.r.l. | |
| PWS Informatica | Brescia |
| PyCon Italia | Florence |
| Pyxlab | Padua |
| Qadra | Turin |
| Qapla’ S.p.A. | |
| Qcom S.p.A. | Bergamo |
| QiNet S.r.l. | Turin |
| QNT S.r.l. | Florence |
| Qodeup | Brescia |
| Quadrivium S.r.l. | Treviso |
| Qualibus | Friuli-Venezia Giulia |
| Qualitas Informatica S.p.A. | Vicenza |
| Quantum Information Group of the University of Rome La Sapienza | Rome |
| Quantum Telecommunications Italy S.r.l. | |
| Quartocanale | Bologna |
| Qubix S.p.A. | Padua |
| Questar S.r.l. | Bergamo |
| Quibee | Turin |
| Quick Algorithm Analytics S.r.l. | |
| Quickfisco | Milan |
| QuoInteligence S.r.l. | |
| R&D Communication S.r.l. | Verona |