| R.Auto.In S.n.c. | Catanzaro |
| R.C.E. Elettronica Professionale | Vicenza |
| Radicalbit S.r.l. | |
| Raffaele Masi | Florence |
| RAMA S.n.c. | Ravenna |
| Ramcube | Milan |
| Rancilio Cube Sicaf S.p.A. | |
| Ranklab Studio | Arezzo |
| Raw Power S.r.l. | Reggio Emilia |
| RCDE S.r.l. | Verona |
| RDS Software Solutions | Modena |
| ReadBeyond | |
| Ready informatica S.r.l. | Lecco |
| Real Estate Documents & Data S.r.l. | |
| Real Web S.r.l. | |
| Realcable S.r.l. | Friuli-Venezia Giulia |
| Realmark | Campobasso |
| Rec Time S.n.c. | Como |
| Reco S.p.A. | Como |
| Recogniform Technologies | Cosenza |
| Recordati Industria Chimica e Farmaceutica S.p.A. | |
| Recordati S.p.A. | |
| Recovery Italia S.r.l. | Rome |
| RecuperaDati.it | Palermo |
| Redco Telematica S.r.l. | Varese |
| Redfish Capital Partners | Milan |
| RedSeed Ventures | Milan |
| Reefilla S.r.l. | |
| Reflab S.r.l. | Pisa |
| Refurbed Marketplace GmbH | |
| Register S.p.A. | Rome |
| Regno.IT | Agrigento |
| ReiThera | Rome |
| Rejoint S.r.l. | |
| REM Graphics S.r.l. | Ancona |
| Remini | Milan |
| Reopla | Turin |
| Reopla S.r.l. | |
| Replica Sistemi S.p.A. | Mantua |
| Reply | Turin |
| Repron Therapeutics | Milan |
| Resalis Therapeutics S.r.l. | |
| RESI S.p.A. | Rome |
| Resin Model S.r.l. | |
| Resplendence Software Projects Sp | Bologna |
| Restworld S.r.l. | |
| Retail Hub S.r.l. | |
| RetAPPs S.r.l. | |
| Retelit S.p.A. | Milan |
| Reti S.p.A. | Varese |