| Sology | Lesser Poland |
| SOLTIX Sp. z o.o. | |
| Solution.pl | |
| SolveQ | |
| Solvti Sp. z o.o. | |
| Solwena Sp. z o.o. | |
| SonarHome S.A. | |
| SONET | Masovian |
| Sony Europe Ltd (Sp. z o.o.) | Masovian |
| Soppo Sp. z o.o. | |
| Sorigo | |
| SOTE | Greater Poland |
| Sotrender | |
| SOULAB | |
| SP Tech Solutions | |
| Space Forest Sp. z o.o. | |
| Space IT | |
| Space3ac | |
| SpaceAdventure | Masovian |
| SpaceFactory CE Sp. z o.o. sp.k. | |
| Spacemind Studio | |
| spaceOS Ltd | |
| Spacive Sp. z o.o. | |
| Sparing Digital | |
| Spark-Tech Sp. z o.o. | |
| Sparkbit | |
| SPARKLAB.PL | |
| Spartańska | |
| Specctrum | Subcarpathian |
| Special Space | |
| Spectator Sp. z o.o. | Lesser Poland |
| SpeedApp Sp. z o.o. | Masovian |
| Speednet Sp. z o.o. | |
| SpeedUp Venture Capital Group | Greater Poland |
| SpeedUpNinja | |
| Spenande Sp. z o.o. | |
| Spica Solutions | |
| Spinney | |
| Spire Capital Partners | |
| SPOC S.A. | |
| Sportdata Serwis Sp. z o.o. | |
| Spółdzielnia Telekomunikacyjna OST | |
| Społeczna Akademia Nauk | |
| Spółka Inżynierów SIM | Lublin |
| Sprawdznas.pl | |
| Sprint S.A. | Warmian-Masurian |
| Sprinter IT Sp. z o.o. | Opole |
| Sputnik Software Sp. z o.o. | Greater Poland |
| Spyrosoft BSG | |
| Spyrosoft BSS | |