| Rozdoum | Kharkiv |
| Rozetka | Kiev |
| RRC | Kiev |
| RTS Ukraine | Kiev |
| RX-NAME | Kiev |
| S&T Ukraine | Kiev |
| Sait | Kiev |
| Sales'Up | |
| Salesforce24 | Lviv |
| Salon-Manager | Kiev |
| Samsung Ukraine | Kiev |
| SAPHIRA Agency | |
| Sapient Pro | |
| Satellite ISP | Dnipropetrovsk |
| Scalabium Software | Kiev |
| Scalefocus AD | |
| School Today | |
| Science and Technology Center in Ukraine | Kiev |
| Screen Interactive | Kharkiv |
| SD Solutions | Kiev |
| SDA Company | Kharkiv |
| SDD Technology | |
| Seedium | |
| Selena | Kiev |
| Seo Audit Conus | Kiev |
| SEOHelp.ua | Kiev |
| Seomix | Kiev |
| SeoProfy | |
| SEOTM | Kiev |
| SeoTOP | Kharkiv |
| Serpstat | |
| Service.so | |
| SET University | |
| Several Clouds | |
| SGAMES | Kiev |
| Shedix.com | Kiev |
| ShiftCMS | Lviv |
| Shop-CommIT . | Kiev |
| SID Venture Partners | |
| Sigma | Kharkiv |
| SignSine | |
| Silença Tech | |
| Simon Kuznets Kharkiv National University of Economics | Kharkiv |
| Simplify | Kiev |
| Singree | Odessa |
| Site-ua.com | Kiev |
| SiteBuilding | Kiev |
| SITV | Sumy |
| SKELAR | |
| Skif ISP | Kiev |