| Name | Region |
|---|---|
| Skif-Service | Kiev |
| Skillers | Kiev |
| SkillsUp | |
| SkillUP | |
| Skirda.NET | Kiev |
| SkySoft.tech | |
| Skytel Service | Kiev |
| SkyUp Studio | Dnipropetrovsk |
| Skywell Software | Kiev |
| SMarket Software | Kiev |
| Smart Engineering Systems | Kiev |
| Smart Rockstars | |
| SmartCoworking | |
| SmartFarming | |
| Smartfin UA | |
| Smartline | Kiev |
| Smartphone | Kiev |
| Smiss Ltd | Kharkiv |
| SocialBoost | |
| Soft Engeneering | Kiev |
| Soft Industry Alliance | Chernihiv |
| soft Xpansion | Kiev |
| Soft навколо | Khmelnytskyi |
| Soft-pro | Kiev |
| SOFT.ua | |
| SoftBalance | Kiev |
| SoftConstruct | |
| Softfree | Kiev |
| Softinform | Kiev |
| Softket | Kiev |
| Softline | |
| SoftList | Kiev |
| SoftLoft | Kharkiv |
| Softonix | Lviv |
| Softproject | Kiev |
| SoftRize | |
| SoftSoul | Kiev |
| Software Expert | Kharkiv |
| Softwarez | Kiev |
| Softwarium | Kiev |
| SoloWay Tech | |
| SolverLabs | Kiev |
| Sombra | |
| Sonettic | Kiev |
| Sorbsys | |
| SOURCE iT | |
| Sovtes | |
| Space Cossacks | |
| Space Electric Thruster Systems | Dnipropetrovsk |
| Spark Mail Ltd |