| Pmigest | Namur |
| PNO Consultants | |
| Point Be S.P.R.L. | Brussels-Capital |
| Point Reclame B.V.B.A. | Limburg |
| Pointerpro | |
| POM N.V. | |
| Positive Thinking Company | |
| Precirix | |
| Preview B.V. | East Flanders |
| Prezly | |
| Prodata Systems | Flemish Brabant |
| Prodetics | Walloon Brabant |
| Prodius | West Flanders |
| ProduWeb | Brussels-Capital |
| Progreso HR Software | |
| Projinit | East Flanders |
| Promes B.V.B.A. | Antwerp |
| Promisys | |
| Prompto | |
| Pronovix Group B.V.B.A. | East Flanders |
| Prosolit | Namur |
| Prospect.io SPRL | Brussels-Capital |
| Protime | |
| Protime S.A. | Antwerp |
| Proximus | Brussels-Capital |
| Proxistore | |
| PS Automation | |
| Ps_testware N.V. | Flemish Brabant |
| PTOLEMUS Consulting Group | |
| Pulisfy Medical | |
| Pulsar Consulting | |
| Pure GraphX B.V. | East Flanders |
| Purna Pharmaceuticals | Antwerp |
| PythonFOSDEM | Brussels-Capital |
| Qbic Venture Partners | East Flanders |
| Qimia AI | |
| Qmino B.V. | Flemish Brabant |
| Qover S.A./N.V. | Brussels-Capital |
| QUAD Belgium N.V./S.A. | East Flanders |
| Qualfocus | Namur |
| Qualifio | Walloon Brabant |
| Quantoom Biosciences | |
| Quantoom Biosciences | |
| QWAY.energy | |
| Rack66 Colocation | East Flanders |
| Radiomics | |
| Radix | |
| Rafusoft | |
| Railnova S.A. | |
| Raincode | Brussels-Capital |