| Raincode Labs | Brussels-Capital |
| Ramasoft | |
| RealDomen | Flemish Brabant |
| Reality Matters | Antwerp |
| Reality Sys S.A. | Liège |
| Recupel | Brussels-Capital |
| Redcorp | Brussels-Capital |
| Référenceur.be S.P.R.L. | Liège |
| Register SA/NV | Brussels-Capital |
| Register.be | Brussels-Capital |
| REIN4CED | |
| Rejuvenate Biomed N.V. | |
| Rekall Design | Antwerp |
| Remmicom | Antwerp |
| reMYND | |
| Replay | |
| Resillion | |
| Restomax | Brussels-Capital |
| Revatis S.A. | |
| Rewind Therapeutics | |
| RheaVita | |
| Riaktr | |
| Rise Financials SRL | |
| Roam B.V.B.A. | Limburg |
| Robarov | Antwerp |
| Robbell | East Flanders |
| Robert Bosch N.V. | Brussels-Capital |
| Robotics & Design BVBA | Antwerp |
| Rock.estate | |
| Roland DG Benelux N.V. | Antwerp |
| Rombit | |
| Roots N.V. | Antwerp |
| Royal Academies for Sciences and Arts of Belgium | Brussels-Capital |
| RTLOC | |
| Ruben Vermeersch | Flemish Brabant |
| Runa | West Flanders |
| Rydoo | Antwerp |
| S-Clinica | |
| S.I. Group S.A. | Liège |
| Sanaware Itsana B.V.B.A. | Flemish Brabant |
| Sanel N.V. | Antwerp |
| Santero Therapeutics S.R.L. | |
| SarrCom.com | Antwerp |
| Satbeams S.P.R.L. | Walloon Brabant |
| Satrabel | Walloon Brabant |
| Savaco | West Flanders |
| ScaleFund | |
| Scarabee Graphic Design | West Flanders |
| Scarlet | Brussels-Capital |
| Schrijf.be | Antwerp |