| Margie Gibb Web Design | Western Cape |
| Maritec Trust | Gauteng |
| Mark Dyer | KwaZulu-Natal |
| MARS Technologies (Pty) Ltd | Eastern Cape |
| Maruti Media | |
| Masete Digital Technologies | |
| Massador Computers | Free State |
| Master Circuits | KwaZulu-Natal |
| MasterGrade IT | Western Cape |
| Masterweb | Western Cape |
| Matogen | Western Cape |
| Matter Industries | |
| MaxiCash | |
| Maxima Software | KwaZulu-Natal |
| Maxitec Internet & Cellular | Western Cape |
| Maxwell | Gauteng |
| Maxxor Software Services | Western Cape |
| Mboneni Teledata | Gauteng |
| MC Designs | Gauteng |
| McComms I.T. Solutions | KwaZulu-Natal |
| MCI | Gauteng |
| MCS Africa | Gauteng |
| MCT Telecommunications | Gauteng |
| MDP Labs | Gauteng |
| MedHold (Pty) Ltd | |
| Medhold Medical (Pty) Ltd | Gauteng |
| Media Axis | Eastern Cape |
| Media Machine | Western Cape |
| MediaFX | Western Cape |
| Megazone Designs | Gauteng |
| Melsoft | |
| Memeburn | Western Cape |
| Memeworx | Western Cape |
| Memtec | Gauteng |
| Metacom | Western Cape |
| MetaImago | |
| Metcore IT Consult | Limpopo |
| METIS Marketing Solutions | Western Cape |
| Metrofile (Pty) Ltd | Free State |
| MFS Africa Ltd | |
| Mfundisi Consulting | Western Cape |
| MG Creations | KwaZulu-Natal |
| MicroAce CC | KwaZulu-Natal |
| Micrographics | Gauteng |
| Micros South Africa | Gauteng |
| Microserve Design Studio | Western Cape |
| MIcrosoft South Africa | Gauteng |
| Microsystems On Silicon (Pty) Ltd | Gauteng |
| MicroVision Software | KwaZulu-Natal |
| MiDAS Management Systems CC | Gauteng |