| Pyfera Capital | |
| Pylon Electronics, Inc. | Ontario |
| Pyon Electric Ltd | |
| Pyradia, Inc. | |
| Pyropus Technology | Saskatchewan |
| Pythian | |
| Pythian Services, Inc. | Ontario |
| PyUp | |
| Pyxis Technologies, Inc. | Quebec |
| Q Blocks | |
| Q College Ltd | British Columbia |
| Q Digital Design Ltd | Alberta |
| Q Kits Ltd | Ontario |
| Q&T Recherche | |
| Q-Block Computing, Inc. | Ontario |
| Q-Surf | Ontario |
| Q.W. Page Associates, Inc. | Ontario |
| Q1 Capital Partners | Ontario |
| Q14 | Quebec |
| Q4 Web Systems | Ontario |
| Q4, Inc. | Ontario |
| Q5 Systems | Newfoundland and Labrador |
| Q8ISMobile, Inc. | Quebec |
| QA Consultants | Ontario |
| QA International | Quebec |
| QAD, Inc. | Ontario |
| QArea Ltd | Ontario |
| Qaujimautik Systems, Inc. | Quebec |
| QB Marketing | Nova Scotia |
| QBuild Software | |
| Qcard, Inc. | |
| QDataHub | |
| QDX Software Solutions | |
| QEData | |
| Qeen Biotechnologies | |
| QEII Health Sciences Centre Foundation | |
| Qeynet, Inc. | |
| QHR Technologies | British Columbia |
| Qikiqtaaluk Corporation | Nunavut |
| Qinfotech Solutions | British Columbia |
| Qiniq | |
| QiQ Communications, Inc. | Ontario |
| QITX, Inc. | Quebec |
| QLogitek | Ontario |
| QNT Software development, Inc. | |
| Qode Media | |
| Qohash, Inc. | Quebec |
| Qoherent | Ontario |
| Qoints | Ontario |
| Qprint | Ontario |