| Sonic Core GmbH | North Rhine-Westphalia |
| Sonicdomains Internetagentur und IT-Service | Lower Saxony |
| Sonntag & Partner Partnerschaftsgesellschaft mbB | |
| Sono Motors GmbH | |
| Soppe & Partner EDV-Beratung GbR | Baden-Württemberg |
| SOPRA EDV-Informationssysteme GmbH | Bavaria |
| Soprado GmbH | Bavaria |
| Soptim AG | North Rhine-Westphalia |
| Sorbisches Institut e.V. / Serbski institut z.t. | |
| SORG Elektrotechnik GmbH | Rhineland-Palatinate |
| Sorgalla jCarousel | Baden-Württemberg |
| sorglosinternet GmbH | |
| SOS Software Service GmbH | Bavaria |
| SoSafe GmbH | |
| SoSy-Lab Software and Computational Systems Lab | |
| SOTEC GmbH | Bavaria |
| SOTEC Software Entwicklungs GmbH + Co | Baden-Württemberg |
| SottMedia | Hamburg |
| SOU AG | Baden-Württemberg |
| Sound- und Webdesign Frank Schattle | Rhineland-Palatinate |
| SoundCloud Global Limited & Co. KG | Berlin |
| Source WorX | Hesse |
| Sourcery Software GmbH | North Rhine-Westphalia |
| Sourcing Management GmbH | Bremen |
| SozialBank AG | |
| Sozialhelden e.V. | |
| SP Data GmbH & Co. KG | North Rhine-Westphalia |
| SP Vertriebs GmbH | Baden-Württemberg |
| SP-Software GmbH | Lower Saxony |
| Space Founders | |
| Space Squad | |
| Space Structures GmbH | |
| Space Tech Expo Europe | |
| Space Ventures GmbH | |
| Space2000 | Mecklenburg-Vorpommern |
| SpaceCAD | Baden-Württemberg |
| spacedealer GmbH | |
| Spacegoats GmbH | |
| SpaceIndex UG (haftungsbeschränkt) | Mecklenburg-Vorpommern |
| SpaceNet AG | Bavaria |
| spacepilots GmbH | |
| SpaceTec Capital GmbH | |
| SpaceWatch.Global GmbH | |
| spaceXmedia | Saarland |
| Spaciv | |
| Spamihilator | Hesse |
| Sparda-Bank Baden-Württemberg eG | Baden-Württemberg |
| Sparda-Bank Berlin eG | Berlin |
| Sparda-Bank Hamburg eG | Hamburg |
| Sparda-Bank Hessen eG | Hesse |