| Sport Software | North Rhine-Westphalia |
| Spot Solutions GmbH | |
| Spotcap Global Services GmbH | |
| Spotty oHG | |
| Sprakelsoft GmbH | |
| Spread GmbH | |
| spree systems GmbH | |
| Spreed.ME | |
| Spring Techno GmbH & Co. KG | |
| Springer Fachmedien Wiesbaden GmbH | |
| SPRT APP GmbH | |
| Spryker Systems GmbH | |
| SPS Electronic GmbH | Baden-Württemberg |
| SPS Soft GmbH | Bavaria |
| SPV Solutions, Products, Visions AG | Bavaria |
| SQL Projekt AG | Saxony |
| SQL-Info.de | Berlin |
| SQLAI.ai | |
| SQLinForm | Hesse |
| SQMOPC | Bavaria |
| Squake.earth GmbH | |
| SquareOne Management GmbH | |
| Squidex UG (haftungbeschränkt) | |
| SR International Services & Repair GmbH | Hesse |
| SRC Security Research & Consulting GmbH | North Rhine-Westphalia |
| SRH Fachschulen GmbH | |
| SRH Fernhochschule - The Mobile University | |
| SRH Hochschule Berlin | Berlin |
| SRH Hochschule in Nordrhein-Westfalen | |
| SRM Printtechnik GmbH & Co. KG | Berlin |
| SRT Resistor Technology GmbH | Bavaria |
| SRWare | |
| SSE - Secure Systems Engineering GmbH | |
| SSH Software und Systemberatung GmbH | Bavaria |
| SST IT-Services AG | Saarland |
| St. Josef Krankenhaus Essen-Werden GmbH | |
| Sta*Ware EDV Beratung GmbH | |
| STABL Energy GmbH | |
| STACKIT | |
| STADA Arzneimittel AG | |
| Stadt.Land.Netz GmbH | |
| Stadtgemüse UG (haftungsbeschränkt) | |
| Stadtmedienzentrum Stuttgart am Landesmedienzentrum Baden-Württemberg | |
| Stadtreinigung Hamburg | |
| Stadtseite | North Rhine-Westphalia |
| Stadtwerke Flensburg GmbH | Schleswig-Holstein |
| Staffbase GmbH | Saxony |
| StageMe GmbH | |
| Stagex Manfred Faulhaber e.K. | North Rhine-Westphalia |
| StahlWorks Technologies | Baden-Württemberg |