| RSight | |
| RTE Services | Alpes-Maritimes |
| RTE Technologies | |
| RTEL | Ille-et-Vilaine |
| Rtone | |
| Rubecom | Val-de-Marne |
| RubenSoft | Hautes-Pyrénées |
| RudeBaguette | Paris |
| Rue du Commerce S.A. | Paris |
| Rumble Studio | |
| Rushmix | |
| Ryax Technologies | |
| Rzilient | |
| S & H Group | Paris |
| S-Designer.com | Hérault |
| S4E - Energysoft | |
| Saagie | |
| Saaswedo | |
| SAB International | Hérault |
| Sabella S.A. | Finistère |
| Sacasa | Eure-et-Loir |
| Safari des métiers du numériques | Loire-Atlantique |
| SAFE | |
| SafeBrands | Paris |
| SafeHeal, Inc. | |
| Safeo | Hauts-de-Seine |
| Safran | |
| Saft | |
| SAFTI | |
| Sagemcom Broadband S.A.S. | Hauts-de-Seine |
| SAGES Informatique | Corse-du-Sud |
| Sagimeca | |
| SAILING communication & technologies | Val-de-Marne |
| Saint-Gobain | |
| SAITEC S.A.R.L. | Saône-et-Loire |
| Salemioche S.A.R.L. | Alpes-Maritimes |
| Salesapps | |
| SalesMind Ai | |
| Salezero | Hauts-de-Seine |
| Salies | Essonne |
| Salon international de l'aéronautique et de l'espace | |
| Sam-Mag.com | Gironde |
| Samabriva | |
| Samabriva | |
| Sami.eco | |
| SAMSYS | |
| Sand to Green | |
| Sangha | Bouches-du-Rhône |
| Sanilea | |
| Sanofi | |