| Seed4Soft | Paris |
| Seedcom | Gard |
| SEEDERAL | |
| Seekyo | |
| SeeLog | Paris |
| SeeWeb | Morbihan |
| Segaby Informatique | Bas-Rhin |
| Ségic Ingénierie | |
| SegmentAction | Paris |
| Segula Technologies | |
| Seica France S.A.R.L. | Yvelines |
| Seicer S.A.S. | Oise |
| SEIITRA | Isère |
| Sekoia.io | |
| Seldon Finance | Pyrénées-Atlantiques |
| Selectour | |
| Selic | Calvados |
| Sellsy | |
| Sellsy | |
| Selva | Loire-Atlantique |
| Semantis | Yvelines |
| SemantiWeb | |
| Semaphors | Ille-et-Vilaine |
| Semply Digital | |
| SemWare S.A.S. | Haute-Garonne |
| SENEF | |
| sennder Technologies GmbH | |
| Sensewaves | |
| SensioGrey | Hauts-de-Seine |
| SensioLabs | Hauts-de-Seine |
| Sensomedia | Haute-Corse |
| Sensories Lab | Paris |
| Sensorion | |
| Senzo | Seine-Saint-Denis |
| SEO Camp | Paris |
| SEO Media S.A.R.L. | Paris |
| Seo Vip | Paris |
| Seo-briques | Maine-et-Loire |
| SEO.fr | Essonne |
| SEOHackers | Yvelines |
| SEOmatic | |
| Seonity | |
| SEOPress | Pyrénées-Atlantiques |
| SEOQuantum | |
| Seprolec | Calvados |
| Septentrion Consultants | Paris |
| Septeo Proptech | |
| Septodont | Val-de-Marne |
| Septodont Holding | |
| SEQENS | |