| SeqOne S.A.S. | |
| Sequans | Hauts-de-Seine |
| Sequentiel | Haute-Savoie |
| Sequoiasoft S.A.S. | Alpes-Maritimes |
| SERB Pharmaceuticals | Paris |
| Serca Informatique | Bouches-du-Rhône |
| Serco Point Web | Métropole de Lyon |
| Serena | Paris |
| Sérénia | Hauts-de-Seine |
| SERES | Val-de-Marne |
| Serious Factory | Hauts-de-Seine |
| Serious Factory S.A.S. | Hauts-de-Seine |
| Serli | Vienne |
| Serma Technologies | Gironde |
| Sertelcom S.A. | Essonne |
| Serveam | Val-d'Oise |
| Servebox | Bouches-du-Rhône |
| Serveur Express | Hauts-de-Seine |
| Serveur Hébergé | Hauts-de-Seine |
| Service Informatique Préfabrication Européenne | Vaucluse |
| ServicePilot | Loire-Atlantique |
| Services Épargne Entreprise (S2E) | |
| Services Épargne Entreprise S.A.S. | |
| Services M.A.C. | Haute-Garonne |
| Servicesmobiles.fr | Paris |
| Sesame it | |
| SESAMm | |
| Sesan | |
| Sesin | Bouches-du-Rhône |
| SET Corporation S.A. | |
| Seventic | Paris |
| Seventure Partners | |
| Sevilog | Bas-Rhin |
| Sewan Groupe | |
| Seyna | |
| Sezem | Puy-de-Dôme |
| SFdesign | Paris |
| SFEIR | Paris |
| SFI | Loire |
| SFR | Paris |
| SFR Biosciences | |
| SFR Business | Paris |
| SFX Création | Ardèche |
| SGPA | |
| SGPI | Ille-et-Vilaine |
| Shadow | |
| Shakebiz | |
| Shakeup Factory | |
| ShakeUpFactory | |
| Shan | |