| Shanaya | Val-de-Marne |
| Shane Graphique | Hauts-de-Seine |
| Shapr | |
| Share it | |
| Share My Space | |
| Shareppy S.A.S. | |
| Sharp Electronics France | Haute-Garonne |
| Sherpa Engineering | Hauts-de-Seine |
| SHF Informatique | Bouches-du-Rhône |
| Shift Technology S.A.S. | Paris |
| Shine | |
| Shipfix Technologies S.A.S. | |
| Shippeo | Paris |
| Shippingbo | |
| Shopopop | |
| ShoWhere | |
| SI.CONTACT | Bouches-du-Rhône |
| Sia Partners | Paris |
| Siamed'Xpress | Bouches-du-Rhône |
| Siamep Multimedia | Bouches-du-Rhône |
| Siatel | Hauts-de-Seine |
| Siberian | |
| SIBIO | Essonne |
| SICEM | |
| SID-Networks | Haute-Garonne |
| Side | |
| Sidely | |
| Siderlog | |
| Sidetrade | Hauts-de-Seine |
| Sidexa | |
| SIDO | Métropole de Lyon |
| Siècle Digital | Ain |
| Sifflet | |
| Sifial | Charente-Maritime |
| SIG-Image | Pyrénées-Atlantiques |
| Sigfox | |
| Sigire | Sarthe |
| SIGMA Clermont | |
| Sigma Gestion | Paris |
| SIGMA-RH | Paris |
| Sigmeo | Haute-Garonne |
| Sigmund | |
| Signal Spam | Paris |
| Signal.fr | |
| Signarama | |
| Signature S.A.S. | Loire |
| Signia Therapeutics | |
| Signoret | Alpes-Maritimes |
| SII | Seine-Saint-Denis |
| Sil'Age | Indre-et-Loire |