| SCINTIL Photonics | |
| Scipio Bioscience | |
| SCJ Informatique | Seine-Maritime |
| SCOP Gassagosso | |
| ScoQi | Seine-Maritime |
| Score & Secure Payment | |
| Score'n'co | |
| Scorvitech S.A.R.L. | Morbihan |
| ScrapingBee | |
| Screenpresso | Haute-Garonne |
| Screenreach Interactive France S.A.S. | |
| Scrypt Media S.A.S. | |
| SCT Telecom | Seine-Saint-Denis |
| SCTEL | Isère |
| Sculpteo | Val-de-Marne |
| SDAI Informatique | Haute-Vienne |
| SDCI | Métropole de Lyon |
| SDI | Var |
| SDI Informatique | Alpes-Maritimes |
| SDI Paris | |
| SDP Games | |
| SDTools | Paris |
| SdV | Bas-Rhin |
| SeaBubbles | |
| Sealk | |
| Sealog | Vienne |
| SEALWeb | |
| Seaport | Yvelines |
| Search Foresight | Hauts-de-Seine |
| Sébastien Moulène. | Paris |
| Seccom | Rhône |
| SECIB | Paris |
| Seclab | |
| Secomp | Seine-et-Marne |
| Second S.A.S. | |
| Section 4 | |
| Sector | Paris |
| Securas Technologies | |
| Secure IC | Ille-et-Vilaine |
| Securinfor | Val-de-Marne |
| Security | Alpes-Maritimes |
| Secuserve | Paris |
| Secuserve S.A.S. | Paris |
| Secutec | Alpes-Maritimes |
| SEDI-ATI | Essonne |
| SEDIA | Paris |
| SEE Critical Comms | Métropole de Lyon |
| See You Sun | |
| Seed in Tech | |
| Seed-Up | |