| SOS-Data | Vienne |
| Sosdonnees | Paris |
| SOTIEG | |
| Sotratech | |
| SOUBABERE Informatique | Gironde |
| Soubeyrand Consultant | Bouches-du-Rhône |
| Source | Seine-Saint-Denis |
| Source Ventures | |
| Souris Kiclic | Allier |
| Sous-titre Webdesign | Paris |
| South Champagne Business School | |
| Southcomp Polaris | Val-de-Marne |
| SOWIT | |
| SP2i | Essonne |
| Space Designer 3D | |
| SpaceFill | |
| SpaceFill | Paris |
| SpaceLocker S.A.S. | |
| SpaceSense | |
| Spallian | Paris |
| SparingVision | |
| Spark Cleantech | |
| SPARKK | |
| Sparklane | Paris |
| Sparkup | |
| Spartel | |
| Spatialist | |
| Specinov | Maine-et-Loire |
| Spedding Research Solutions S.A.S. | |
| Speechi | Nord |
| Speeral | Gard |
| Spendesk | Paris |
| SPGL InformatiK | Loire-Atlantique |
| Sphere Informatique | Gironde |
| SPHEREA | |
| Sphinx Manager | Bouches-du-Rhône |
| SPI | Haute-Garonne |
| Spiders | Paris |
| SPIE ICS | Hauts-de-Seine |
| Spigao | Haute-Garonne |
| Spigraph France S.A.S. | Isère |
| SpikImm | |
| Spindata | Yvelines |
| SpineGuard S.A. | |
| SpinFire | Gironde |
| Spintec | |
| Spirea | |
| Spirica | |
| Splash Internet | Tarn |
| Splio | Paris |