| Splio | |
| SPOKE | |
| SPooN | |
| Spore.Bio | |
| SportEasy S.A.S. | |
| Sportheroes | Paris |
| Sprintvision | Val-d'Oise |
| SPV Informatique | Bas-Rhin |
| SQI IT Solutions | Yvelines |
| SQLI | Hauts-de-Seine |
| SQLiteManager | Paris |
| Squad | |
| Squall Network | Vienne |
| Squardata | |
| Square Partners | Pyrénées-Orientales |
| Squey | |
| Sqwad | |
| SRCI | |
| SRD | Nord |
| SRI International Sarnoff | |
| SS2i Services | Charente-Maritime |
| ST-Telecoms | Yvelines |
| Stabler Technologies S.A.S. | |
| Stackr | Ain |
| STAE Toulouse | Haute-Garonne |
| StaffMe | |
| Stage11 S.A.S. | |
| Stago | |
| Stampyt S.A.S. | Loire-Atlantique |
| Stanwell Consulting | |
| Star-Achats S.A.R.L. | |
| Starboost S.A.R.L. | |
| Starclay | |
| Starform | Hauts-de-Seine |
| Starseed | |
| Start in Paris | Paris |
| Start-up | Ille-et-Vilaine |
| StarTech Normandy | Orne |
| StartHer | Paris |
| Startin’Blox | |
| Startup Academy | Paris |
| Startup For Kids | |
| Startup Inside | |
| Startup Sesame | Paris |
| Startup.info | Paris |
| Startup365 | Haute-Garonne |
| StartupBRICS | Bouches-du-Rhône |
| StartupVillage | |
| Startx | |
| Starware It Services | |