| Creativo Multimedia | Florida |
| Crunchloop | |
| CUE, Ltda | Montevideo |
| Cuti | Montevideo |
| Cygno Solutions | Montevideo |
| Cygnus | Montevideo |
| Cziber | Montevideo |
| D11 | Montevideo |
| Dahseo | |
| Daniel Costas | Montevideo |
| Datalogic Software | Montevideo |
| Datasur | Montevideo |
| Datos.gub.uy | Montevideo |
| Decodeuy S.R.L. | Montevideo |
| Del Plata Office | |
| Derebaja.com | Montevideo |
| Desarrollo Web Uruguay | Montevideo |
| Dev Sprouts, S.A.S. | |
| Devsys Compliance Technology | Montevideo |
| Digital Outlet | Montevideo |
| Dinámica Consultores S.R.L. | Montevideo |
| Dirección General de Educación Técnico Profesional – UTU | |
| dLab Software | |
| doIT Innovations | |
| Dokier | Montevideo |
| Dot Qual Servicios Informaticos | Montevideo |
| DROMOS | |
| duodynIT | Montevideo |
| DVelop | Montevideo |
| Dynatech | Montevideo |
| e-commerce Uruguay | Montevideo |
| e-Lace Media Services | |
| e2T | Montevideo |
| EasyMail S.A Uruguay | Montevideo |
| Effective | Montevideo |
| Effectus Software | |
| Eidos.ai | Montevideo |
| Ekko Agency | Montevideo |
| El Mate Creativos | Montevideo |
| Elcabo | Montevideo |
| ELE10 Digital Media | Montevideo |
| Element 14 | |
| EME Studio | |
| Emprehost | Montevideo |
| enBuscadores.net | Montevideo |
| Endeavor Uruguay | |
| Enlace | Montevideo |
| Enlace Uruguay | Montevideo |
| Ensamble Uruguay Ltda | Montevideo |
| Entrust | |