| Sharman | Montevideo |
| Sharman Development Studio | |
| Silver/River | |
| SimDesign | Montevideo |
| Simplifica Software | Montevideo |
| Sinergia | |
| Sistemas Informáticos S.R.L. | Montevideo |
| Sitios | Montevideo |
| Sitios Web Uruguay | Montevideo |
| SlideModel | |
| Smart Talent | |
| Smart Up Software | |
| SMSUruguay | Montevideo |
| Social Media UY | |
| Sofis Solutions | Montevideo |
| Sofis Solutions | |
| SoftCargo | Montevideo |
| Softron Uruguay | Montevideo |
| Software Testing Bureau | Montevideo |
| Solcre | |
| Somnio Software | Montevideo |
| Space | Montevideo |
| SpaceDev Ltda | Montevideo |
| Standing | |
| StoreOne | Montevideo |
| Streaver | |
| Suárez&Clavera | |
| Sublime Solutions | Montevideo |
| Sustancia X | |
| SV4 | Montevideo |
| Switch Software | |
| Systems X | Montevideo |
| TEDx Montevideo | |
| Tensai | Montevideo |
| Terminus Labs | |
| Tero | |
| ThalesLab | Montevideo |
| Thaloz | |
| The Good Guys | |
| ThinkUp | |
| Thot S.R.L. | Montevideo |
| Tilso, S.A. | Montevideo |
| TodoSoft Uruguay | Montevideo |
| Tokai Ventures | |
| TQM | Montevideo |
| TranZa | Montevideo |
| Treeview | Montevideo |
| Trepcom | |
| Tribus IT Solutions | Montevideo |
| Trupropel | |