| Epson Europe Electronics GmbH | Bavaria |
| ept GmbH | Bavaria |
| epublica GmbH | Hamburg |
| Epunks GmbH | North Rhine-Westphalia |
| Epyxs GmbH | |
| Equada GmbH | Bavaria |
| EQUIcon Software GmbH | Thuringia |
| Equiduct | |
| Equinox FinTech Solutions GmbH | |
| Equinux Aktiengesellschaft | Bavaria |
| equipme GmbH | |
| Erasys GmbH | |
| Erath Organisation GmbH | Hesse |
| Erbe Elektromedizin GmbH | |
| ERDMANN-Softwaregesellschaft mbH | Saxony |
| Eresult GmbH | Lower Saxony |
| ERFTmedien.de | North Rhine-Westphalia |
| ERGO SOFT Softwareentwicklung GmbH | Bavaria |
| ERGON Datenprojekte GmbH | |
| ERIC Group GmbH | |
| Eric Python IDE | Bavaria |
| ErichsenDigital | North Rhine-Westphalia |
| erioTec GmbH | |
| Erler GmbH | Baden-Württemberg |
| Erma Electronic GmbH | Baden-Württemberg |
| Ermer GmbH | Bavaria |
| ERNI Electronics GmbH & Co. KG | Baden-Württemberg |
| Ernst & Engbring GmbH & Co. KG | North Rhine-Westphalia |
| Ernst Klöcker | Berlin |
| Ernst-Abbe-Hochschule Jena | |
| Ernst-Moritz-Arndt-Universität Greifswald - Institut für Mathematik und Informatik | Mecklenburg-Vorpommern |
| ERP4all Business Software GmbH | North Rhine-Westphalia |
| ERS Electronic GmbH | Bavaria |
| Erste Seite Internet Marketing GmbH | Baden-Württemberg |
| ESA BIC Bavaria | |
| ESB EDV-Service Burkart | Baden-Württemberg |
| ESB Student Consulting e. V. | |
| ESC Barcode GmbH | Baden-Württemberg |
| ESC EDV-Systemanalyse & Consulting GmbH | |
| Escape Computer | North Rhine-Westphalia |
| Escar | |
| Eschenburg Elektro-Kälte-Klima GmbH | |
| ESCP Business School | |
| ESCRYPT GmbH | North Rhine-Westphalia |
| ESGendium GmbH | |
| Esker Software GmbH | Bavaria |
| ESL Gaming GmbH | |
| ESMT Berlin | Berlin |
| eSol GmbH | Bavaria |
| Esono AG | Baden-Württemberg |