| Savv-e | New South Wales |
| Savvient Technologies Pty Ltd | |
| Savvy Brains | |
| Savy Soda | Victoria |
| Saxons | New South Wales |
| SaYa Solutions | |
| Scalabl | |
| Scale & Swing | Victoria |
| Scale Ability | |
| Scale Investors Ltd | Victoria |
| Scaleup Consulting | |
| ScanLink Technologies | Tasmania |
| SCANN3D | Victoria |
| Schatz Forensic Pty Ltd | Queensland |
| SchoolBench | |
| Science Publication Pty Ltd | |
| Scinogy | Victoria |
| Scintilla | New South Wales |
| Scion | |
| Scomac Automation | New South Wales |
| Scorched Media | |
| Scott Shorter | |
| Scout7 | |
| Scraping Solutions | |
| ScreenApp | |
| Scriptive | |
| SCSI Integration Pty Ltd | Victoria |
| SDIP Innovations Pty Ltd | New South Wales |
| Seamer Design | Victoria |
| Search Engine Experts Pty Ltd | |
| Search Factory | Queensland |
| Search Internet | |
| Search365 | Queensland |
| Search7 Pty Ltd | Queensland |
| searchcode | |
| Searcht | |
| Secure Access | Queensland |
| Secure Code Warrior | New South Wales |
| Secure Code Warrior | |
| Secure Computer Recycling and Disposal | Western Australia |
| Secure eHost Pty Ltd | South Australia |
| Secure Systems | Western Australia |
| Security Centric | New South Wales |
| Security Communication Solutions International | Victoria |
| Security Strategies | Victoria |
| SecurityBlogs.com.au | |
| SecuTech Solutions Pty Ltd | New South Wales |
| Seedlab Australia | |
| SEEK Ltd | |
| Seers Group Australia Pty Ltd | New South Wales |