| Qualitrain | Mexico City |
| Qualtec | Mexico City |
| Quanticus | Querétaro |
| Quarksoft, S.A P.I de C.V. | Mexico City |
| Quik Internet | Mexico City |
| Quipus S.A. | Mexico City |
| Quo Digital | Mexico City |
| R2 | Mexico City |
| Ralps | Mexico City |
| RC Consulting | Mexico City |
| RCTech | Nuevo León |
| Realhost | Nuevo León |
| RealNet, S.A. de C.V. | Nuevo León |
| Recycletech | Mexico City |
| Red de Universidades Anáhuac | |
| Red2000 | Sinaloa |
| Rednet | Chihuahua |
| Redwood Ventures | Jalisco |
| Resuelve Tu Deuda | Mexico City |
| Reto Zapopan | Jalisco |
| Retry Pay, S.A.P.I. de C.V. | |
| REWORTH | Mexico City |
| roadcasting, S.A. de C.V. | State of Mexico |
| Rocket | Mexico City |
| Rosaura Zapata Cano | |
| Rueda y Asociados | Mexico City |
| Runa | Mexico City |
| Saccsa Software | Mexico City |
| SAFE Consulting Group | Mexico City |
| SAISA PC Shop | Mexico City |
| SAIT Software Administration | Mexico City |
| SAIT Software Administrativo | Nuevo León |
| Saldo.MX | |
| Saltillo Hosting and Evaluacion On-line, S.A. de C.V. | Coahuila |
| Salud Fácil | |
| Sampson Multimedia | Aguascalientes |
| Sanrom's Software de México | Quintana Roo |
| Scala Learning | |
| ScanMex, S.A. de C.V. | Mexico City |
| Scientec | Mexico City |
| Scotiabank México | Mexico City |
| Search de México S.A de C.V. | Mexico City |
| Secretaría de Educación, Ciencia, Tecnología e Innovación de la CDMX | Mexico City |
| Secretaría de Innovación, Ciencia y Tecnología | Mexico City |
| Secure Information Technologies | Mexico City |
| Seecom | Mexico City |
| Seguridad Informática y Desarrollo de Software, S. de R. L. de C. V. | Mexico City |
| SeguriSata | Mexico City |
| Senefex | Nuevo León |
| SEO Simple | Mexico City |