| Serfimex Capital | |
| Servcom Web | State of Mexico |
| Servicios Corporativos Computacionales | Tamaulipas |
| Servicios de Software Ehecatl, S.A de C.V. | Veracruz |
| Servicios Especializados en Sistemas y Organizacion, S.A. de C.V. | Mexico City |
| Servicios Interactivos de Mexico S.A.de C.V. | Mexico City |
| Servicios Internet México | Mexico City |
| ServNet México, S.A. de C.V. | Mexico City |
| Servo Informatica, S.A. de C.V. | Mexico City |
| SG Software Guru | Mexico City |
| ShopMani | Mexico City |
| Siavcom Software | Jalisco |
| SICMX | Nuevo León |
| SIECCOM Monterrey, S.A. de C.V. | Nuevo León |
| Siembra Capitales | Jalisco |
| Sien Electronics | Mexico City |
| Sienlinea.com | Nuevo León |
| SimanG8 | Jalisco |
| Simplemente S.A. de C.V. | Mexico City |
| Sinfin Web | Mexico City |
| Sintegra | Mexico City |
| Siscon | Mexico City |
| SistelNet | Mexico City |
| Sistema Educativo San Pablo | |
| Sistema Integral | Baja California |
| Sistemas Avanzados y Proyectos | Mexico City |
| Sistemas de Automatización | Nuevo León |
| Sistemas de Computación Accesibles del Noroeste, S.C. | Sonora |
| Sistemas de Information Monarch | Mexico City |
| Sistemas Modernos | Sonora |
| Sistemas Phoenix S. de R.L. | Mexico City |
| Sistemas Proactivos Ingenieria y Proyectos, S.A. de C.V. | Querétaro |
| SistemasPC | State of Mexico |
| Sistemex | Yucatán |
| Sitio Mac | Mexico City |
| Sitios Regios | Nuevo León |
| Skydropx | Nuevo León |
| Skye Group | |
| SkyTel Cloud | Mexico City |
| SLM | State of Mexico |
| Smart Center | Mexico City |
| Smart Impact | Mexico City |
| Social Black | Mexico City |
| Sociedad Matemática Mexicana | Mexico City |
| Softelligence | Mexico City |
| Softtek | Mexico City |
| Software DSI, S.A. de C.V. | State of Mexico |
| Soldiers Field Angels | Mexico City |
| Solemti | Sinaloa |
| Solid Servicios | Jalisco |