| Soluciona | Mexico City |
| Soluciones Avanzadas de México Asociados en Cómputo e Informática | Mexico City |
| Soluciones en Sistemas de Identificación, S.A. de C.V. | Mexico City |
| Soluciones Integrales de Informatica y Sistemas S de RL de CV | Jalisco |
| Soluciones Radix, S.A. de C.V. | Mexico City |
| Soluciones Via Internet, S.A. de C.V. | Mexico City |
| SoluTio | Mexico City |
| Solution | Nuevo León |
| Solvento | |
| SOME | Querétaro |
| Sophitech | |
| Sorotech | Mexico City |
| Spacioss Coworking | |
| Sparklabs Agencia Digital | Mexico City |
| Spectron Desarrollo, S.C. | |
| Spheres | Quintana Roo |
| SpicyMinds | Mexico City |
| SpinDigital | Puebla |
| Spiral Media Labs | Sinaloa |
| Sr. Pago | Mexico City |
| StarMedios.com | Tlaxcala |
| StarNet | Mexico City |
| Start Up Solutions | Mexico City |
| Startup Baja | Baja California |
| Startup Mexico | Mexico City |
| Startup Studio Monterrey, S.A.P.I. de C.V. | Nuevo León |
| StartupGDL | Jalisco |
| StartupLab MX | San Luis Potosí |
| StartupLab MX | |
| STC | Mexico City |
| Stendhal Pharma | Mexico City |
| StockWare S.A. de C.V. | Mexico City |
| Stori | Mexico City |
| STX, Soluciones en Línea | Jalisco |
| Style One | Baja California Sur |
| Suempresa.com | Mexico City |
| Supercep, S.A. de C.V. | Mexico City |
| Supercomputo On Line, S.A. de C.V. | Oaxaca |
| SuperTasas | Nuevo León |
| Sustam, S.A de C.V. | Jalisco |
| Swap | |
| Swichi Eléctrica de México | Mexico City |
| Sys&Web | Mexico City |
| Sys.Net.Mx, S. de R.L. de C.V. | Mexico City |
| Syscap | |
| T-Systems México | Puebla |
| Tagwizz | Mexico City |
| Talent Land | |
| Talent Network | Jalisco |
| Talently | |